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AVALIDE contains both irbesartan (an angiotensin II receptor antagonist) and hydrochlorothiazide (a thiazide diuretic). When administered during the second or third trimester of pregnancy, drugs that act directly on the renin-angiotensin system (RAS) can cause fetal and neonatal morbidity and death. AVALIDE prescription and dosage information for physicians and health care professionals. Pharmacology, adverse reactions, warnings, and AVALIDEside effects. Avalide is a combination medication containing irbesartan and hydrochlorothiazide. It's used to treat high blood pressure (hypertension). Irbesartan is an angiotensin receptor blocker (ARB) that relaxes blood vessels to lower blood pressure. Hydrochlorothiazide is a diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. 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